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    lipl-3 Lipase lipl-3 [ Caenorhabditis elegans ]

    Gene ID: 178572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lipl-3
    Official Full Name
    Lipase lipl-3
    Primary source
    WormBase:WBGene00020016
    Locus tag
    CELE_R11G11.14
    See related
    AllianceGenome:WB:WBGene00020016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Involved in lipid catabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lipl-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (521595..524218, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Nuclear Hormone Receptor family Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Secreted protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans. Buis A, et al. Cell Rep, 2019 Jul 23. PMID 31340142, Free PMC Article
    2. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. O'Rourke EJ, et al. Nat Cell Biol, 2013 Jun. PMID 23604316, Free PMC Article
    3. Surviving starvation simply without TFEB. Soukas AA, et al. PLoS Biol, 2019 May. PMID 31136567, Free PMC Article
    4. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions. Mony VK, et al. Proc Natl Acad Sci U S A, 2021 Oct 12. PMID 34607947, Free PMC Article
    5. HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence. Gerisch B, et al. Dev Cell, 2020 May 4. PMID 32302543

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
      Title: Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lipase lipl-3
    NP_503233.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      521595..524218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070832.4 → NP_503233.1  Lipase lipl-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503233.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16956
      Conserved Domains (1) summary
      PLN02872
      Location:10 → 390
      PLN02872; triacylglycerol lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16956.2

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