set-6 Histone-lysine N-methyltransferase set-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: set-6
Official Full Name: Histone-lysine N-methyltransferase set-6
Primary source: WormBase:WBGene00008206
Locus tag: CELE_C49F5.2
See related: AllianceGenome:WB:WBGene00008206
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables histone H3K9 dimethyltransferase activity and histone H3K9 trimethyltransferase activity. Involved in epigenetic regulation of gene expression. Located in chromatin. Is expressed in embryonic cell; gonad; muscle cell; nervous system; and sperm. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See set-6 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (11970077..11974679, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a neuronal epigenetic reader, BAZ-2, and a neuronal histone 3 lysine 9 methyltransferase, SET-6, accelerate behavioural deterioration in C. elegans by reducing mitochondrial function, repressing the expression of nuclear-encoded mitochondrial proteins; genome-wide RNA-interference screen in C. elegans has unravelled conserved epigenetic negative regulators of ageing, suggesting possible ways to achieve healthy ageing
Title: Two conserved epigenetic regulators prevent healthy ageing.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C49F5.2 (e-PCR)
- UniSTS:309343

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables histone H3 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K9 dimethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 trimethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9me2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Histone-lysine N-methyltransferase set-6

NP_510003.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11970077..11974679 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077602.6 → NP_510003.2 Histone-lysine N-methyltransferase set-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510003.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O17679

Conserved Domains (1) summary

smart00317
Location:455 → 603

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain