tag-325 Rho-GAP domain-containing protein;WW domain-containing protein tag-325 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tag-325
Official Full Name: Rho-GAP domain-containing protein;WW domain-containing protein tag-325
Primary source: WormBase:WBGene00008006
Locus tag: CELE_C38D4.5
See related: AllianceGenome:WB:WBGene00008006
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be active in cytoplasm and plasma membrane. Orthologous to several human genes including ARHGAP12 (Rho GTPase activating protein 12); ARHGAP27 (Rho GTPase activating protein 27); and ARHGAP9 (Rho GTPase activating protein 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tag-325 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (4796836..4802907)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3097 (e-PCR)
- UniSTS:515645

C38D4.5 (e-PCR)
- UniSTS:313832

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rho-GAP domain-containing protein;WW domain-containing protein tag-325

NP_001309440.1

Confirmed by transcript evidence

NP_001309595.1

Confirmed by transcript evidence

NP_001309596.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4796836..4802907

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322567.3 → NP_001309440.1 WW domain-containing protein tag-325 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P46941

Conserved Domains (4) summary

cd04403
Location:611 → 825

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:391 → 509

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:407 → 508

PH; PH domain

pfam00397
Location:101 → 130

WW; WW domain
NM_001322568.2 → NP_001309595.1 WW domain-containing protein tag-325 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P46941

UniProtKB/TrEMBL

A0A131MCR8

Conserved Domains (4) summary

cd04403
Location:609 → 823

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:389 → 507

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:405 → 506

PH; PH domain

pfam00397
Location:99 → 128

WW; WW domain
NM_001322570.3 → NP_001309596.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MCX1

Conserved Domains (1) summary

cl02570
Location:92 → 306

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...