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    snb-2 V-SNARE coiled-coil homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snb-2
    Official Full Name
    V-SNARE coiled-coil homology domain-containing protein
    Primary source
    WormBase:WBGene00004898
    Locus tag
    CELE_F23H12.1
    See related
    AllianceGenome:WB:WBGene00004898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1) and VAMP3 (vesicle associated membrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snb-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (12344188..12345908, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Mitochondrial import receptor subunit TOM20 homolog Neighboring gene IncG Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Collagen triple helix repeat protein;Cuticle collagen 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-SNARE coiled-coil homology domain-containing protein
    NP_506093.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12344188..12345908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073692.6 → NP_506093.2  V-SNARE coiled-coil homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506093.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19767, Q7KIS0, Q9NGU4
      Conserved Domains (1) summary
      cd15870
      Location:28 → 90
      R-SNARE_VAMP2; SNARE motif of VAMP2
    Nucleotide Protein
    Heading Accession and Version

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