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    ppm-1.A Protein phosphatase ppm-1.A [ Caenorhabditis elegans ]

    Gene ID: 179469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppm-1.A
    Official Full Name
    Protein phosphatase ppm-1.A
    Primary source
    WormBase:WBGene00006460
    Locus tag
    CELE_F25D1.1
    See related
    AllianceGenome:WB:WBGene00006460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of stress-activated MAPK cascade. Predicted to be located in synapse. Predicted to be active in cytosol and nucleus. Is expressed in anal depressor muscle; hypodermis; intestine; nervous system; and pharynx. Orthologous to several human genes including PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) and PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ppm-1.A in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (10532890..10536388, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Histone deacetylase domain-containing protein Neighboring gene Interleukin-17 Neighboring gene MFS transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway. Baker ST, et al. Genetics, 2015 Jan. PMID 25339611, Free PMC Article
    2. PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans. Tulgren ED, et al. Genetics, 2011 Dec. PMID 21968191, Free PMC Article
    3. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Asencio C, et al. Cell, 2012 Jul 6. PMID 22770216
    4. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. Szewczyk NJ, et al. J Exp Biol, 2006 Oct. PMID 17023606
    5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein phosphatase ppm-1.A
    NP_001023842.1
    • Confirmed by transcript evidence
    NP_001023843.1
    • Confirmed by transcript evidence
    NP_001122929.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10532890..10536388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028671.4 → NP_001023842.1  Protein phosphatase ppm-1.A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WHR6, Q19775, Q7JLJ3
      Conserved Domains (2) summary
      pfam00481
      Location:105 → 374
      PP2C; Protein phosphatase 2C
      cl29762
      Location:375 → 412
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    2. NM_001028672.8 → NP_001023843.1  Protein phosphatase ppm-1.A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19775
      Conserved Domains (2) summary
      pfam00481
      Location:6 → 273
      PP2C; Protein phosphatase 2C
      cl29762
      Location:274 → 311
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    3. NM_001129457.4 → NP_001122929.1  Protein phosphatase ppm-1.A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19775
      Conserved Domains (2) summary
      pfam00481
      Location:22 → 291
      PP2C; Protein phosphatase 2C
      cl29762
      Location:292 → 329
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19775.1

    Gene LinkOut

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