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    grld-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grld-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00017929
    Locus tag
    CELE_F29C4.7
    See related
    AllianceGenome:WB:WBGene00017929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Located in nucleus. Is expressed in epithelial cell; lateral ganglion; muscle cell; and neurons. Orthologous to human RBM15 (RNA binding motif protein 15) and RBM15B (RNA binding motif protein 15B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See grld-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (121797..125931, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Cytoplasmic tRNA 2-thiolation protein 1 Neighboring gene ncRNA Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GRLD-1 regulates cell-wide abundance of glutamate receptor through post-transcriptional regulation. Wang GJ, et al. Nat Neurosci, 2010 Dec. PMID 21037582, Free PMC Article
    2. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Samuelson AV, et al. Cold Spring Harb Symp Quant Biol, 2007. PMID 18419309
    3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_741283.1
    • Confirmed by transcript evidence
    NP_741284.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      121797..125931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171237.8 → NP_741283.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYB8
      Conserved Domains (3) summary
      cd12310
      Location:253 → 324
      RRM3_Spen; RNA recognition motif 3 in the Spen (split end) protein family
      pfam07744
      Location:376 → 482
      SPOC; SPOC domain
      cl17169
      Location:167 → 246
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_171238.5 → NP_741284.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXG5
      Conserved Domains (2) summary
      cd12310
      Location:253 → 324
      RRM3_Spen; RNA recognition motif 3 in the Spen (split end) protein family
      cl17169
      Location:167 → 246
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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