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    spt-16 FACT complex subunit spt-16 [ Caenorhabditis elegans ]

    Gene ID: 172984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spt-16
    Official Full Name
    FACT complex subunit spt-16
    Primary source
    WormBase:WBGene00018849
    Locus tag
    CELE_F55A3.3
    See related
    AllianceGenome:WB:WBGene00018849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleosome binding activity. Involved in nematode pharynx development; positive regulation of chromosome segregation; and regulation of embryonic development. Located in nucleus. Is expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spt-16 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (10789130..10793152)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene C2H2-type domain-containing protein Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene Major sperm protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FACT complex gene duplicates exhibit redundant and non-redundant functions in C. elegans. Suggs BZ, et al. Dev Biol, 2018 Dec 15. PMID 30336114, Free PMC Article
    2. Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis. Krüger AV, et al. Dev Biol, 2015 Feb 15. PMID 25446273
    3. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article
    4. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    5. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FACT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FACT complex subunit spt-16
    NP_492821.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10789130..10793152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060420.5 → NP_492821.1  FACT complex subunit spt-16 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492821.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N5R9
      Conserved Domains (5) summary
      COG5406
      Location:8 → 1013
      COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
      cd01091
      Location:178 → 419
      CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.
      pfam08512
      Location:808 → 889
      Rtt106; Histone chaperone Rttp106-like
      pfam08644
      Location:534 → 689
      SPT16; FACT complex subunit (SPT16/CDC68)
      pfam14826
      Location:8 → 165
      FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N5R9.1

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