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    kars-1 Lysine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 174159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kars-1
    Official Full Name
    Lysine--tRNA ligase
    Primary source
    WormBase:WBGene00002238
    Locus tag
    CELE_T02G5.9
    See related
    AllianceGenome:WB:WBGene00002238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysine-tRNA ligase activity and tRNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode larval development; and regulation of brood size. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in mitochondrion. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kars-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (7070183..7072415, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene fatty Acid CoA Synthetase family Neighboring gene MutS protein homolog him-14 Neighboring gene Nanos-type domain-containing protein Neighboring gene Acetyl-CoA acetyltransferase homolog, mitochondrial Neighboring gene Acetyl-CoA C-acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Rousakis A, et al. Aging Cell, 2013 Oct. PMID 23692540, Free PMC Article
    2. Caenorhabditis elegans evolves a new architecture for the multi-aminoacyl-tRNA synthetase complex. Havrylenko S, et al. J Biol Chem, 2011 Aug 12. PMID 21685384, Free PMC Article
    3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    4. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of brood size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lysine--tRNA ligase
    NP_495453.1
    • Partially confirmed by transcript evidence
    NP_495454.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7070183..7072415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063052.5 → NP_495453.1  Lysine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22099
      Conserved Domains (3) summary
      PLN02502
      Location:1 → 557
      PLN02502; lysyl-tRNA synthetase
      cd00775
      Location:216 → 555
      LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
      cd04322
      Location:104 → 213
      LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

    2. NM_063053.6 → NP_495454.1  Lysine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495454.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZQ3
      Conserved Domains (4) summary
      PLN02502
      Location:35 → 581
      PLN02502; lysyl-tRNA synthetase
      cd00775
      Location:240 → 579
      LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
      cd04322
      Location:128 → 237
      LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
      cl03428
      Location:17 → 97
      MAS20; MAS20 protein import receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22099.1

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