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    abts-4 Anion exchange protein [ Caenorhabditis elegans ]

    Gene ID: 180943, updated on 4-Jan-2025

    Summary

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    Official Symbol
    abts-4
    Official Full Name
    Anion exchange protein
    Primary source
    WormBase:WBGene00019844
    Locus tag
    CELE_R03E9.3
    See related
    AllianceGenome:WB:WBGene00019844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Located in basolateral plasma membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; osteopetrosis; and renal tubular acidosis. Orthologous to several human genes including SLC4A2 (solute carrier family 4 member 2) and SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See abts-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    20
    Sequence:
    Chromosome: X; NC_003284.9 (6747296..6761738, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Mad-like protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inward rectifier potassium channel irk-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The abts and sulp families of anion transporters from Caenorhabditis elegans. Sherman T, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15814591
    2. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Anion exchange protein
    NP_001024826.2
    • Confirmed by transcript evidence
    NP_001123169.1
    • Partially confirmed by transcript evidence
    NP_001123170.1
    • Partially confirmed by transcript evidence
    NP_001380003.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6747296..6761738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029655.6 → NP_001024826.2  Anion exchange protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58QG8
      Conserved Domains (3) summary
      TIGR00834
      Location:81 → 955
      ae; anion exchange protein
      pfam07565
      Location:100 → 365
      Band_3_cyto; Band 3 cytoplasmic domain
      cl23746
      Location:415 → 879
      HCO3_cotransp; HCO3- transporter family

    2. NM_001129697.5 → NP_001123169.1  Anion exchange protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58G79
      Conserved Domains (3) summary
      TIGR00834
      Location:81 → 935
      ae; anion exchange protein
      pfam07565
      Location:186 → 365
      Band_3_cyto; Band 3 cytoplasmic domain
      cl23746
      Location:415 → 873
      HCO3_cotransp; HCO3- transporter family

    3. NM_001392793.1 → NP_001380003.1  Anion exchange protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q45EK3
      Conserved Domains (1) summary
      cl23746
      Location:414 → 865
      Xan_ur_permease; Permease family

    4. NM_001129698.4 → NP_001123170.1  Anion exchange protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0C4
      Conserved Domains (3) summary
      TIGR00834
      Location:81 → 873
      ae; anion exchange protein
      pfam07565
      Location:186 → 365
      Band_3_cyto; Band 3 cytoplasmic domain
      cl23746
      Location:415 → 873
      HCO3_cotransp; HCO3- transporter family
    Nucleotide Protein
    Heading Accession and Version

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