unc-130 Forkhead box protein unc-130 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-130
Official Full Name: Forkhead box protein unc-130
Primary source: WormBase:WBGene00006853
Locus tag: CELE_C47G2.2
See related: AllianceGenome:WB:WBGene00006853
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Involved in several processes, including axon extension involved in axon guidance; negative regulation of transcription by RNA polymerase II; and nematode male tail tip morphogenesis. Located in nucleus. Is expressed in several structures, including embryonic cell; hypodermis; neurons; ray; and ventral body wall muscle. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to several human genes including FOXD3 (forkhead box D3); FOXD4 (forkhead box D4); and FOXD4L1 (forkhead box D4 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-130 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (11281966..11283959)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcription factor unc-130/FOXD3/4 contributes to the biphasic calcium response required to optimize avoidance behavior.
Title: The transcription factor unc-130/FOXD3/4 contributes to the biphasic calcium response required to optimize avoidance behavior.
Lineage-specific control of convergent differentiation by a Forkhead repressor.
Title: Lineage-specific control of convergent differentiation by a Forkhead repressor.
Widespread, cis-acting elements in the unc-130 promoter positively regulate ventral body wall muscle expression and negatively regulate dorsal body wall muscle expression. This pattern is required to establish the dorsal-ventral polarity of UNC-129/TGF-beta. UNC-130 is not required post-embryonically to maintain the asymmetry of body wall muscle unc-129 expression.
Title: Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C47G2.2 (e-PCR)
- UniSTS:313900

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Forkhead box protein unc-130

NP_496411.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11281966..11283959

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064010.5 → NP_496411.1 Forkhead box protein unc-130 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496411.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18694

Conserved Domains (2) summary

COG5025
Location:126 → 330

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cl00061
Location:127 → 222

FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins