unc-8 Degenerin unc-8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-8
Official Full Name: Degenerin unc-8
Primary source: WormBase:WBGene00006748
Locus tag: CELE_R13A1.4
See related: AllianceGenome:WB:WBGene00006748
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ligand-gated sodium channel activity. Involved in locomotion and neuron remodeling. Located in neuronal cell body. Is expressed in neurons. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 22

Sequence:: Chromosome: IV; NC_003282.8 (7197153..7203660)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The epithelial Na[+] channel UNC-8 promotes an endocytic mechanism that recycles presynaptic components to new boutons in remodeling neurons.
Title: The epithelial Na(+) channel UNC-8 promotes an endocytic mechanism that recycles presynaptic components to new boutons in remodeling neurons.
The authors propose that the depolarizing effect of UNC-8-dependent sodium import elevates intracellular calcium in a positive feedback loop involving the voltage-gated calcium channel UNC-2 and the calcium-activated phosphatase TAX-6/calcineurin to initiate a caspase-dependent mechanism that disassembles the presynaptic apparatus.
Title: The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons.
Neurotoxic UNC-8(G387E) and UNC-8(A586T)mutants encode hyperactivated channels blocked by extracellular calcium and magnesium.
Title: Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13A1.4 (e-PCR)
- UniSTS:305694

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: Degenerin unc-8

NP_001294292.1

Confirmed by transcript evidence

NP_001294293.1

Confirmed by transcript evidence

NP_001294294.1

Confirmed by transcript evidence

NP_501138.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7197153..7203660

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307363.3 → NP_001294292.1 Degenerin unc-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294292.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PE10

Conserved Domains (2) summary

TIGR00867
Location:105 → 714

deg-1; degenerin

cl02990
Location:98 → 717

ASC; Amiloride-sensitive sodium channel
NM_001307364.3 → NP_001294293.1 Degenerin unc-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294293.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PAS5

Conserved Domains (2) summary

TIGR00867
Location:107 → 716

deg-1; degenerin

cl02990
Location:100 → 719

ASC; Amiloride-sensitive sodium channel
NM_068737.2 → NP_501138.1 Degenerin unc-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501138.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21974, U4PAS5, U4PB70, U4PE10

Conserved Domains (2) summary

TIGR00867
Location:106 → 715

deg-1; degenerin

cl02990
Location:99 → 718

ASC; Amiloride-sensitive sodium channel
NM_001307365.3 → NP_001294294.1 Degenerin unc-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294294.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PB70

Conserved Domains (2) summary

TIGR00867
Location:66 → 675

deg-1; degenerin

cl02990
Location:59 → 678

ASC; Amiloride-sensitive sodium channel