rars-2 arginine--tRNA ligase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rars-2
Official Full Name: arginine--tRNA ligase
Primary source: WormBase:WBGene00004680
Locus tag: CELE_C29H12.1
See related: AllianceGenome:WB:WBGene00004680
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rars-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (6125559..6127942)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C29H12.1 (e-PCR)
- UniSTS:308660

C29H12.2 (e-PCR)
- UniSTS:308661

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables arginine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arginyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: arginine--tRNA ligase

NP_495227.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6125559..6127942

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062826.6 → NP_495227.1 arginine--tRNA ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495227.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18316

Conserved Domains (1) summary

COG0018
Location:28 → 512

ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]