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    npr-9 Galanin-like G-protein coupled receptor npr-9 [ Caenorhabditis elegans ]

    Gene ID: 191320, updated on 27-Dec-2024

    Summary

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    Official Symbol
    npr-9
    Official Full Name
    Galanin-like G-protein coupled receptor npr-9
    Primary source
    WormBase:WBGene00013974
    Locus tag
    CELE_ZK455.3
    See related
    AllianceGenome:WB:WBGene00013974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in foraging behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in AIBL and AIBR. Human ortholog(s) of this gene implicated in nicotine dependence and opiate dependence. Orthologous to several human genes including GALR2 (galanin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npr-9 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (11329724..11332169)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sphingomyelin phosphodiesterase 2 Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Receptor-type guanylate cyclase gcy-9 Neighboring gene ncRNA Neighboring gene Cytoplasmic aconitate hydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NPR-9 regulates the innate immune response in Caenorhabditis elegans by antagonizing the activity of AIB interneurons. Yu Y, et al. Cell Mol Immunol, 2018 Jan. PMID 27133473, Free PMC Article
    2. A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues. Bendena WG, et al. Proc Natl Acad Sci U S A, 2008 Jan 29. PMID 18216257, Free PMC Article
    3. NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans. Campbell JC, et al. PLoS Genet, 2016 May. PMID 27223098, Free PMC Article
    4. Induction of Protective Response Associated with Expressional Alterations in Neuronal G Protein-Coupled Receptors in Polystyrene Nanoparticle Exposed Caenorhabditis elegans. Yang Y, et al. Chem Res Toxicol, 2021 May 17. PMID 33650869
    5. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NPR-9 regulates the innate immune response by antagonizing the activity of AIB interneurons.
      Title: NPR-9 regulates the innate immune response in Caenorhabditis elegans by antagonizing the activity of AIB interneurons.
    2. We also assessed ionotropic glutamate receptor GLR-1 cell-specifically within AIB and determined that GLR-1 fine-tunes AIB activity to modify locomotion following reversal events. Our research highlights that signal integration underlying the initiation and fine-tuning of backwards locomotion is AIB and NPR-9 dependent, and has demonstrated the suitability of C. elegans for analysis of multisensory integration
      Title: NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in foraging behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Galanin-like G-protein coupled receptor npr-9
    NP_001361821.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11329724..11332169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375132.1 → NP_001361821.1  Galanin-like G-protein coupled receptor npr-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23497
      Conserved Domains (1) summary
      cd15096
      Location:30 → 340
      7tmA_AstA_R_insect; allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23497.2

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