mec-7 Tubulin beta-1 chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-7
Official Full Name: Tubulin beta-1 chain
Primary source: WormBase:WBGene00003171
Locus tag: CELE_ZK154.3
See related: AllianceGenome:WB:WBGene00003171
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Located in neuron projection and neuronal cell body. Is expressed in BDU and mechanosensory neurons. Used to study hypokalemic periodic paralysis. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness; complex cortical dysplasia with other brain malformations 6; congenital symmetric circumferential skin creases 1; hypomyelinating leukodystrophy 6; and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa); TUBB4B (tubulin beta 4B class IVb); and TUBB (tubulin beta class I). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mec-7 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (7774856..7776689, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEC-7 integrity is necessary for the correct number of neurites a neuron generates in vivo and for the capacity of an axon to regenerate.
Title: A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons.
Data show that all mec-15 phenotypes can be dominantly suppressed by mutations in mec-7, which encodes a beta-tubulin, and dominantly enhanced by mutations in mec-12, which encodes an alpha-tubulin.
Title: mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS6-12 (e-PCR)
- UniSTS:242499

ZK154.3 (e-PCR)
- UniSTS:312485

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tubulin beta-1 chain

NP_509313.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7774856..7776689 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076912.5 → NP_509313.1 Tubulin beta-1 chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509313.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P12456

Conserved Domains (2) summary

PLN00220
Location:1 → 426

PLN00220; tubulin beta chain; Provisional

cd02187
Location:2 → 426

beta_tubulin; The beta-tubulin family