osm-9 Ion transport domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: osm-9
Official Full Name: Ion transport domain-containing protein
Primary source: WormBase:WBGene00003889
Locus tag: CELE_B0212.5
See related: AllianceGenome:WB:WBGene00003889
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium channel activity and temperature-gated cation channel activity. Involved in several processes, including heat acclimation; olfactory learning; and sensory perception of smell. Located in neuronal cell body; non-motile cilium; and perinuclear region of cytoplasm. Is expressed in RIG; head mesodermal cell; rectal gland cell; sensory neurons; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV3 (transient receptor potential cation channel subfamily V member 3); TRPV4 (transient receptor potential cation channel subfamily V member 4); and TRPV5 (transient receptor potential cation channel subfamily V member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See osm-9 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 14

Sequence:: Chromosome: IV; NC_003282.8 (3551090..3557431, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OSM-9 and an amiloride-sensitive channel, DEG-1, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons.
Title: OSM-9 and an amiloride-sensitive channel, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons.
Mutations in osm-9 and osm-12 that disrupt amphid neurons-mediated hypertonic avoidance behavior or genetic ablation of amphid neurons are associated with enhanced survival during hypertonic stress.
Title: Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis.
The aromatic residues in the OSM-9 nociception selectivity filter are critical for pain behavior and ion permeation.
Title: TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.
Loss of both osm-9 and ocr-2 resulted in a robust extension of lifespan up to 32% compared to control C. elegans animals.
Title: TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling.
Loss of GRK-2 function may lead to changes in gene expression, via OSM-9/OCR-2, to selectively alter the levels of signaling components that transduce or regulate bitter taste responses.
Title: Caenorhabditis elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling.
Data report cell-specific regulation of serotonin biosynthesis by the transient receptor potential V (TRPV) ion channels encoded by the osm-9 and ocr-2 genes in C. elegans.
Title: Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0212.5 (e-PCR)
- UniSTS:308827

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables temperature-gated cation channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in heat acclimation	IDA Inferred from Direct Assay more info	PubMed
involved_in heat acclimation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative adaptation of signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative adaptation of signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ion transport domain-containing protein

NP_500372.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3551090..3557431 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067971.4 → NP_500372.1 Ion transport domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500372.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBV8, G5EGK2

Conserved Domains (2) summary

TIGR00870
Location:49 → 789

trp; transient-receptor-potential calcium channel protein

sd00045
Location:171 → 202

ANK; ANK repeat [structural motif]