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    gcy-19 Guanylate cyclase [ Caenorhabditis elegans ]

    Gene ID: 191650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-19
    Official Full Name
    Guanylate cyclase
    Primary source
    WormBase:WBGene00001544
    Locus tag
    CELE_C17F4.6
    See related
    AllianceGenome:WB:WBGene00001544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-19 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    23
    Sequence:
    Chromosome: II; NC_003280.10 (3250975..3259354, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Secreted protein Neighboring gene Citrate-sodium symporter;MFS transporter;SLC36A1 Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases. Ortiz CO, et al. Curr Biol, 2009 Jun 23. PMID 19523832, Free PMC Article
    2. Cis-regulatory mechanisms of left/right asymmetric neuron-subtype specification in C. elegans. Etchberger JF, et al. Development, 2009 Jan. PMID 19060335, Free PMC Article
    3. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, et al. Genetics, 2006 May. PMID 16547101, Free PMC Article
    4. The neural basis of heat seeking in a human-infective parasitic worm. Bryant AS, et al. Curr Biol, 2022 May 23. PMID 35483361, Free PMC Article
    5. Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Inada H, et al. Genetics, 2006 Apr. PMID 16415369, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Guanylate cyclase
    NP_001348700.1
    • Confirmed by transcript evidence
    NP_001348701.1
    • Confirmed by transcript evidence
    NP_001348702.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3250975..3259354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361853.3 → NP_001348700.1  Guanylate cyclase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16544
      UniProtKB/TrEMBL
      A0A2K5ATP8
      Conserved Domains (3) summary
      cd06352
      Location:45 → 461
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:870 → 1059
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl21453
      Location:565 → 835
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001361852.3 → NP_001348701.1  Guanylate cyclase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16544
      UniProtKB/TrEMBL
      A0A2K5ATR8
      Conserved Domains (3) summary
      cd06352
      Location:45 → 456
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:865 → 1054
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl21453
      Location:560 → 830
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001361854.3 → NP_001348702.1  Guanylate cyclase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16544
      UniProtKB/TrEMBL
      A0A2K5ATQ4
      Conserved Domains (3) summary
      cd06352
      Location:45 → 467
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:876 → 1065
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl21453
      Location:571 → 841
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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