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    ceh-12 Homeobox domain-containing protein;Homeobox protein ceh-12 [ Caenorhabditis elegans ]

    Gene ID: 172255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-12
    Official Full Name
    Homeobox domain-containing protein;Homeobox protein ceh-12
    Primary source
    WormBase:WBGene00000436
    Locus tag
    CELE_F33D11.4
    See related
    AllianceGenome:WB:WBGene00000436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sequence-specific double-stranded DNA binding activity. Involved in neuron fate specification. Predicted to be active in nucleus. Is expressed in VB neuron; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (5840282..5841940)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Oxysterol-binding protein Neighboring gene Potassium channel domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene DUF4263 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression in vitro of a gene encoding tRNAArgACG from the nematode Caenorhabditis elegans. Schaller D, et al. Gene, 1991 Jan 15. PMID 1999292
    2. Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans. Schaller D, et al. Nucleic Acids Res, 1990 Apr 25. PMID 1970877, Free PMC Article
    3. UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit. Schneider J, et al. Development, 2012 Jun. PMID 22619391, Free PMC Article
    4. UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans. Von Stetina SE, et al. Genes Dev, 2007 Feb 1. PMID 17289921, Free PMC Article
    5. Caenorhabditis elegans has scores of homoeobox-containing genes. Bürglin TR, et al. Nature, 1989 Sep 21. PMID 2571091

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox domain-containing protein;Homeobox protein ceh-12
    NP_001309522.1
    • Confirmed by transcript evidence
    NP_491693.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5840282..5841940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059292.2 → NP_491693.1  Homeobox protein ceh-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491693.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17487, Q9TZZ7
      Conserved Domains (1) summary
      pfam00046
      Location:113 → 166
      Homeobox; Homeobox domain

    2. NM_001322676.1 → NP_001309522.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MAP5
      Conserved Domains (1) summary
      pfam00046
      Location:4 → 58
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17487.2

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