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    ceh-40 Homeobox protein ceh-40 [ Caenorhabditis elegans ]

    Gene ID: 191624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-40
    Official Full Name
    Homeobox protein ceh-40
    Primary source
    WormBase:WBGene00000461
    Locus tag
    CELE_F17A2.5
    See related
    AllianceGenome:WB:WBGene00000461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dopaminergic neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-40 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (12318126..12320777, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 14 Neighboring gene pseudo Neighboring gene MX region of TRA-2 Related Neighboring gene Uncharacterized protein Neighboring gene Serpentine receptor class delta-40 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Aspöck G, et al. Development, 2003 Aug. PMID 12810585
    2. Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Liu H, et al. Development, 2006 Feb. PMID 16421192
    3. A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans. Doitsidou M, et al. Genes Dev, 2013 Jun 15. PMID 23788625, Free PMC Article
    4. Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Van Auken K, et al. Development, 2002 Nov. PMID 12399316
    5. Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20. Jiang Y, et al. Mech Dev, 2008 May-Jun. PMID 18316179, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein ceh-40
    NP_510060.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12318126..12320777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077659.4 → NP_510060.1  Homeobox protein ceh-40 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510060.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19503
      Conserved Domains (2) summary
      cd00086
      Location:188 → 249
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:5 → 186
      PBC; PBC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19503.1

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