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    nhr-1 Nuclear hormone receptor family member nhr-1;Nuclear receptor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-1
    Official Full Name
    Nuclear hormone receptor family member nhr-1;Nuclear receptor domain-containing protein
    Primary source
    WormBase:WBGene00003600
    Locus tag
    CELE_R09G11.2
    See related
    AllianceGenome:WB:WBGene00003600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in regulation of response to osmotic stress. Predicted to be located in nucleus. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (17519735..17528197)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Putative potassium channel regulatory protein sup-10 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved nuclear hormone receptors controlling a novel plastic trait target fast-evolving genes expressed in a single cell. Sieriebriennikov B, et al. PLoS Genet, 2020 Apr. PMID 32282814, Free PMC Article
    2. Feeding-structure morphogenesis in "rhabditid" and diplogastrid nematodes is not controlled by a conserved genetic module. Theska T, et al. Evol Dev, 2024 Mar. PMID 38356318
    3. Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. Burton NO, et al. Nat Commun, 2018 Dec 4. PMID 30514845, Free PMC Article
    4. Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans. Gómez-Escribano AP, et al. EMBO Rep, 2023 Jun 5. PMID 37103980, Free PMC Article
    5. Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Miyabayashi T, et al. Dev Biol, 1999 Nov 15. PMID 10545240

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-1;Nuclear receptor domain-containing protein
    NP_001024853.1
    • Confirmed by transcript evidence
    NP_001024855.1
    • Confirmed by transcript evidence
    NP_001367802.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      17519735..17528197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029682.6 → NP_001024853.1  Nuclear hormone receptor family member nhr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21878, Q867F1, Q86PL0, Q86PL1
      Conserved Domains (2) summary
      cd06960
      Location:73 → 153
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:252 → 414
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001029684.7 → NP_001024855.1  Nuclear hormone receptor family member nhr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21878
      Conserved Domains (2) summary
      cd06960
      Location:73 → 148
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:247 → 409
      HOLI; Ligand binding domain of hormone receptors

    3. NM_001381184.1 → NP_001367802.1  Nuclear receptor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JYA7
      Conserved Domains (2) summary
      cd06960
      Location:73 → 148
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      pfam00104
      Location:230 → 271
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21878.4

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