U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    acr-20 AcetylCholine Receptor [ Caenorhabditis elegans ]

    Gene ID: 187632, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    acr-20
    Official Full Name
    AcetylCholine Receptor
    Primary source
    WormBase:WBGene00000059
    Locus tag
    CELE_R06A4.10
    See related
    AllianceGenome:WB:WBGene00000059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See acr-20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (14373831..14377896, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pre-mRNA 3' end processing protein pfs-2 Neighboring gene SPK domain-containing protein Neighboring gene Importin N-terminal domain-containing protein Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Histone-lysine N-methyltransferase mes-2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors. Baur R, et al. Mol Pharmacol, 2015 Jan. PMID 25352042
    2. Drug-dependent behaviors and nicotinic acetylcholine receptor expressions in Caenorhabditis elegans following chronic nicotine exposure. Polli JR, et al. Neurotoxicology, 2015 Mar. PMID 25530353, Free PMC Article
    3. The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Francis MM, et al. Neuron, 2005 May 19. PMID 15944127
    4. Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans. Mongan NP, et al. Protein Sci, 2002 May. PMID 11967372, Free PMC Article
    5. The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. Culetto E, et al. J Biol Chem, 2004 Oct 8. PMID 15280391

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    AcetylCholine Receptor
    NP_001022273.1
    • Product from WormBase gene class acr;
      Confirmed by transcript evidence
    NP_001366936.1
    • Product from WormBase gene class acr;
      Confirmed by transcript evidence
    NP_001367183.1
    • Product from WormBase gene class acr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14373831..14377896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381655.1 → NP_001366936.1  AcetylCholine Receptor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6QWI5, Q9U398
      Conserved Domains (2) summary
      cd18997
      Location:7 → 195
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor
      cd19051
      Location:197 → 287
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC

    2. NM_001027102.7 → NP_001022273.1  AcetylCholine Receptor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022273.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6QWI5, Q7JKI4
      Conserved Domains (2) summary
      pfam02931
      Location:6 → 196
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:230 → 287
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. NM_001381654.1 → NP_001367183.1  AcetylCholine Receptor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1Q281, Q6QWI5
      Conserved Domains (2) summary
      cd19051
      Location:239 → 329
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
      pfam02931
      Location:24 → 238
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools