fat-7 Delta(9)-fatty-acid desaturase fat-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fat-7
Official Full Name: Delta(9)-fatty-acid desaturase fat-7
Primary source: WormBase:WBGene00001399
Locus tag: CELE_F10D2.9
See related: AllianceGenome:WB:WBGene00001399
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables stearoyl-CoA 9-desaturase activity. Involved in fatty acid biosynthetic process and post-embryonic development. Acts upstream of or within intracellular oxygen homeostasis and response to hypoxia. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fat-7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (7151353..7153146, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homeostatic control of stearoyl desaturase expression via patched-like receptor PTR-23 ensures the survival of C. elegans during heat stress.
Title: Homeostatic control of stearoyl desaturase expression via patched-like receptor PTR-23 ensures the survival of C. elegans during heat stress.
Butein inhibits lipogenesis in Caenorhabditis elegans.
Title: Butein inhibits lipogenesis in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F10D2.9 (e-PCR)
- UniSTS:309650

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEA Inferred from Electronic Annotation more info
enables stearoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular oxygen homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Delta(9)-fatty-acid desaturase fat-7

NP_504814.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

7151353..7153146 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072413.7 → NP_504814.1 Delta(9)-fatty-acid desaturase fat-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504814.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGH6

Conserved Domains (1) summary

cd03505
Location:73 → 313

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...