U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    basl-1 Aromatic-L-amino-acid decarboxylase [ Caenorhabditis elegans ]

    Gene ID: 175779, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    basl-1
    Official Full Name
    Aromatic-L-amino-acid decarboxylase
    Primary source
    WormBase:WBGene00015467
    Locus tag
    CELE_C05D2.3
    See related
    AllianceGenome:WB:WBGene00015467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aromatic-L-amino-acid decarboxylase activity. Predicted to be involved in catecholamine metabolic process and serotonin biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See basl-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (5614948..5617261)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene X chromosome NonDisjunction factor Neighboring gene DUF3598 domain-containing protein Neighboring gene Aromatic-L-amino-acid decarboxylase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Function and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in Caenorhabditis. Hare EE, et al. BMC Evol Biol, 2004 Aug 2. PMID 15287963, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aromatic-L-amino-acid decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in catecholamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serotonin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Aromatic-L-amino-acid decarboxylase
    NP_498210.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5614948..5617261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065809.5 → NP_498210.1  Aromatic-L-amino-acid decarboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45138
      Conserved Domains (1) summary
      cl18945
      Location:1 → 508
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools