nduv-2 putative NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nduv-2
Official Full Name: putative NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Primary source: WormBase:WBGene00009992
Locus tag: CELE_F53F4.10
See related: AllianceGenome:WB:WBGene00009992
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Orthologous to human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nduv-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (13624625..13625567, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53F4.12 (e-PCR)
- UniSTS:311750

F53F4.10 (e-PCR)
- UniSTS:320987

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: putative NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

NP_506376.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13624625..13625567 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073975.7 → NP_506376.1 putative NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506376.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20719

Conserved Domains (2) summary

COG1905
Location:42 → 200

NuoE; NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]

pfam01257
Location:52 → 198

2Fe-2S_thioredx; Thioredoxin-like [2Fe-2S] ferredoxin