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    mig-13 Abnormal cell migration protein 13 [ Caenorhabditis elegans ]

    Gene ID: 180755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-13
    Official Full Name
    Abnormal cell migration protein 13
    Primary source
    WormBase:WBGene00003245
    Locus tag
    CELE_F43C9.4
    See related
    AllianceGenome:WB:WBGene00003245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of cell migration. Located in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including QR.a; QR.p; QR.pa; neurons; and pharyngeal-intestinal valve. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-13 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (4796099..4799646, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Calmodulin;EF-hand domain-containing protein Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toward Universal Forward Genetics: Using a Draft Genome Sequence of the Nematode Oscheius tipulae To Identify Mutations Affecting Vulva Development. Besnard F, et al. Genetics, 2017 Aug. PMID 28630114, Free PMC Article
    2. Spatial confinement of receptor activity by tyrosine phosphatase during directional cell migration. Zhu Z, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513699, Free PMC Article
    3. A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans. Zhou X, et al. FEBS Lett, 2016 Jan. PMID 26762178
    4. Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Wang X, et al. Proc Natl Acad Sci U S A, 2013 Jul 2. PMID 23784779, Free PMC Article
    5. MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans. Masuda H, et al. FEBS Lett, 2012 Mar 23. PMID 22293500

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIG-13, an evolutionarily conserved transmembrane protein, cell-autonomously regulates the asymmetric distribution of the actin cytoskeleton in the leading migratory edge.
      Title: Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.
    2. Data suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
      Title: MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Abnormal cell migration protein 13
    NP_001024660.1
    • Confirmed by transcript evidence
    NP_001024661.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4796099..4799646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029489.7 → NP_001024660.1  Abnormal cell migration protein 13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024660.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EF33, H2KZ96
      Conserved Domains (2) summary
      smart00192
      Location:183 → 213
      LDLa; Low-density lipoprotein receptor domain class A
      smart00042
      Location:52 → 172
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein

    2. NM_001029490.5 → NP_001024661.1  Abnormal cell migration protein 13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EF33
      Conserved Domains (2) summary
      smart00192
      Location:177 → 207
      LDLa; Low-density lipoprotein receptor domain class A
      smart00042
      Location:46 → 166
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EF33.1

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