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    mfap-1 Microfibrillar-associated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mfap-1
    Official Full Name
    Microfibrillar-associated protein 1
    Primary source
    WormBase:WBGene00009671
    Locus tag
    CELE_F43G9.10
    See related
    AllianceGenome:WB:WBGene00009671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in body wall musculature; intestine; pharynx; and vulval muscle. Orthologous to human MFAP1 (microfibril associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mfap-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (8638514..8640236, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene Calponin-homology (CH) domain-containing protein Neighboring gene GCF C-terminal domain-containing protein Neighboring gene t-SNARE coiled-coil homology domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. Ma L, et al. PLoS Genet, 2012. PMID 22829783, Free PMC Article
    2. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Joseph-Strauss D, et al. Dev Biol, 2012 May 15. PMID 22426005, Free PMC Article
    3. The extracellular matrix phenome across species. Statzer C, et al. Matrix Biol Plus, 2020 Nov. PMID 33543035, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our studies indicate that C. elegans mfap-1 encodes a splicing factor that can affect alternative splicing
      Title: The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Microfibrillar-associated protein 1
    NP_492340.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8638514..8640236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059939.9 → NP_492340.1  Microfibrillar-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492340.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93712
      Conserved Domains (1) summary
      pfam06991
      Location:220 → 427
      MFAP1; Microfibril-associated/Pre-mRNA processing
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93712.1

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