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    kle-2 Condensin-2 complex subunit kle-2 [ Caenorhabditis elegans ]

    Gene ID: 176116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kle-2
    Official Full Name
    Condensin-2 complex subunit kle-2
    Primary source
    WormBase:WBGene00016202
    Locus tag
    CELE_C29E4.2
    See related
    AllianceGenome:WB:WBGene00016202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity. Involved in mitotic sister chromatid segregation. Predicted to be located in chromosome, centromeric region. Predicted to be part of condensin complex. Predicted to be active in nucleus. Orthologous to human NCAPH2 (non-SMC condensin II complex subunit H2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kle-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (7941717..7945593)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative galactocerebrosidase Neighboring gene Protein FMC1 homolog Neighboring gene Glutathione transferase omega-1 Neighboring gene Putative cuticle collagen 90 Neighboring gene Adenylate kinase Neighboring gene DUF2189 domain-containing protein Neighboring gene C6 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans Gonad Dissection and Freeze Crack for Immunofluorescence and DAPI Staining. Ananthaswamy D, et al. J Vis Exp, 2022 Sep 16. PMID 36190281, Free PMC Article
    2. Genome-wide analysis of condensin binding in Caenorhabditis elegans. Kranz AL, et al. Genome Biol, 2013. PMID 24125077, Free PMC Article
    3. A global chromatin compaction pathway that represses germline gene expression during starvation. Belew MD, et al. J Cell Biol, 2021 Sep 6. PMID 34128967, Free PMC Article
    4. A highly efficient multifunctional tandem affinity purification approach applicable to diverse organisms. Ma H, et al. Mol Cell Proteomics, 2012 Aug. PMID 22474084, Free PMC Article
    5. Two classes of dosage compensation complex binding elements along Caenorhabditis elegans X chromosomes. Blauwkamp TA, et al. Mol Cell Biol, 2009 Apr. PMID 19188444, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A global chromatin compaction pathway that represses germline gene expression during starvation.
      Title: A global chromatin compaction pathway that represses germline gene expression during starvation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Condensin-2 complex subunit kle-2
    NP_498727.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7941717..7945593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066326.9 → NP_498727.2  Condensin-2 complex subunit kle-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498727.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34341
      Conserved Domains (2) summary
      pfam06278
      Location:17 → 110
      CNDH2_N; Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
      pfam16858
      Location:706 → 806
      CNDH2_C; Condensin II complex subunit CAP-H2 or CNDH2, C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34341.2

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