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    elo-6 Long chain fatty acid elongase 6 [ Caenorhabditis elegans ]

    Gene ID: 177321, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elo-6
    Official Full Name
    Long chain fatty acid elongase 6
    Primary source
    WormBase:WBGene00001244
    Locus tag
    CELE_F41H10.8
    See related
    AllianceGenome:WB:WBGene00001244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid elongase activity. Involved in methyl-branched fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in amphid neurons; intestine; nerve ring; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elo-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (5386629..5388559, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CACTA en-spm transposon protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HORMA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans. Kong W, et al. Nat Commun, 2024 Nov 2. PMID 39488532, Free PMC Article
    2. EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment. Cao X, et al. Cell Mol Life Sci, 2023 Jul 14. PMID 37450052, Free PMC Article
    3. Monomethyl branched-chain fatty acids are critical for Caenorhabitis elegans survival in elevated glucose conditions. Vieira AFC, et al. J Biol Chem, 2022 Feb. PMID 34826420, Free PMC Article
    4. Modulation of Neurotransmitter Pathways and Associated Metabolites by Systemic Silencing of Gut Genes in C. elegans. Shukla S, et al. Diagnostics (Basel), 2023 Jul 10. PMID 37510066, Free PMC Article
    5. Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Pauli F, et al. Development, 2006 Jan. PMID 16354718, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans.
      Title: ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans.
    2. elo-5 and elo-6 may be transcriptional targets of LPD-1
      Title: Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methyl-branched fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Long chain fatty acid elongase 6
    NP_500797.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5386629..5388559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068396.8 → NP_500797.1  Long chain fatty acid elongase 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20303
      Conserved Domains (1) summary
      pfam01151
      Location:33 → 262
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20303.1

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