dop-1 Dopamine receptor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dop-1
Official Full Name: Dopamine receptor 1
Primary source: WormBase:WBGene00001052
Locus tag: CELE_F15A8.5
See related: AllianceGenome:WB:WBGene00001052
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gs; epinephrine binding activity; and norepinephrine binding activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; habituation; and mechanosensory behavior. Predicted to be located in membrane and synapse. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including accessory cell; excretory gland cell; head muscle; intestine; and neurons. Human ortholog(s) of this gene implicated in Parkinson's disease; attention deficit hyperactivity disorder; blepharospasm; hypertension; and kidney failure. Orthologous to several human genes including DRD1 (dopamine receptor D1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dop-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (4411301..4418851, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of food on adaptation are affected by dopamine signaling; dopamine acts via the DOP-1 receptor to decrease adaptation on food.
Title: Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans.
NLP-12 release from DVA is regulated through the D1-like dopamine receptor DOP-1, and both nlp-12 and dop-1 are required for normal local food searching responses
Title: A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior.
Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans.
Title: Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans.
The dop-1 receptor modulates the plasticity of mechanosensory behavior.
Title: Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.

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General gene information

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Markers

F15A8.5 (e-PCR)
- UniSTS:320042

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA Inferred from Direct Assay more info	PubMed
enables epinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables norepinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to food	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dopamine receptor 1

NP_001024578.1

Confirmed by transcript evidence

NP_001024579.1

Confirmed by transcript evidence

NP_001370620.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4411301..4418851 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029407.4 → NP_001024578.1 Dopamine receptor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024578.1

Status: REVIEWED

Conserved Domains (1) summary

cd15065
Location:7 → 333

7tmA_Ap5-HTB1-like; serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001383561.1 → NP_001370620.1 Dopamine receptor 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86ME4, Q86ME5, Q86ME6

Conserved Domains (1) summary

cd15065
Location:7 → 391

7tmA_Ap5-HTB1-like; serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001029408.5 → NP_001024579.1 Dopamine receptor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024579.1

Status: REVIEWED

Conserved Domains (1) summary

cd15065
Location:7 → 333

7tmA_Ap5-HTB1-like; serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors