hst-1 Heparan sulfate N-sulfotransferase 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: hst-1
Official Full Name: Heparan sulfate N-sulfotransferase 1
Primary source: WormBase:WBGene00002028
Locus tag: CELE_F08B4.6
See related: AllianceGenome:WB:WBGene00002028
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to several human genes including NDST1 (N-deacetylase and N-sulfotransferase 1); NDST2 (N-deacetylase and N-sulfotransferase 2); and NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparin biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_501491.4

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The following sections contain reference sequences that belong to a specific genome build. Explain