U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lin-2 Protein lin-2 [ Caenorhabditis elegans ]

    Gene ID: 181400, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lin-2
    Official Full Name
    Protein lin-2
    Primary source
    WormBase:WBGene00002991
    Locus tag
    CELE_F17E5.1
    See related
    AllianceGenome:WB:WBGene00002991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables insulin-like growth factor receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to membrane. Located in cell junction. Is expressed in several structures, including body wall musculature; isthmus; neurons; somatic nervous system; and vulval precursor cell. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lin-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    25
    Sequence:
    Chromosome: X; NC_003284.9 (12399517..12414041, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase nekl-3 Neighboring gene putative calcium-binding mitochondrial carrier F17E5.2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caenorhabditis elegans LIN-2A and mammalian neuronal CASK are prototypical members of a subfamily of MAGUKs (membrane-associated guanylate kinases) characterized by a common kinase-like domain and a guanylate kinase domain predicted to bind ATP. Baines AJ. Biochem J, 1996 Dec 1. PMID 8973587, Free PMC Article
    2. A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. Petrosky KY, et al. J Biol Chem, 2005 Nov 18. PMID 16147993
    3. Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Zaborin A, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19369215, Free PMC Article
    4. CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission. Li L, et al. PLoS Genet, 2022 Oct. PMID 36279278, Free PMC Article
    5. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Kaech SM, et al. Cell, 1998 Sep 18. PMID 9753323, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIN-2 and SYD-2 both positively affect the velocity of UNC-104
      Title: Identification and Characterization of LIN-2(CASK) as a Regulator of Kinesin-3 UNC-104(KIF1A) Motility and Clustering in Neurons.
    2. Data suggest distinctive function of LIN-12 signaling in specification of HCG fates.
      Title: Re-programming of C. elegans male epidermal precursor fates by Wnt, Hox, and LIN-12/Notch activities.
    3. analysis of the solution structure of the heterodimer composed of the L27 domains from LIN-2 and LIN-7
      Title: A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to basolateral plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Protein lin-2
    NP_001024587.1
    • Confirmed by transcript evidence
    NP_001024588.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12399517..12414041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029416.4 → NP_001024587.1  Protein lin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54936
      Conserved Domains (7) summary
      cd12035
      Location:637 → 712
      SH3_MPP1-like; Src Homology 3 domain of Membrane Protein, Palmitoylated 1 (or MAGUK p55 subfamily member 1)-like proteins
      smart00072
      Location:783 → 947
      GuKc; Guanylate kinase homologues
      smart00220
      Location:19 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00595
      Location:546 → 624
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:773 → 948
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:431 → 478
      L27; L27 domain
      cl21453
      Location:13 → 312
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001029417.4 → NP_001024588.1  Protein lin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024588.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54936
      Conserved Domains (5) summary
      cd12035
      Location:296 → 371
      SH3_MPP1-like; Src Homology 3 domain of Membrane Protein, Palmitoylated 1 (or MAGUK p55 subfamily member 1)-like proteins
      smart00072
      Location:442 → 606
      GuKc; Guanylate kinase homologues
      pfam00595
      Location:205 → 283
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:432 → 607
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:90 → 137
      L27; L27 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54936.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous