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    plpp-1.1 Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plpp-1.1
    Official Full Name
    Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
    Primary source
    WormBase:WBGene00018756
    Locus tag
    CELE_F53C3.13
    See related
    AllianceGenome:WB:WBGene00018756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including PLPP1 (phospholipid phosphatase 1) and PLPP2 (phospholipid phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See plpp-1.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (3919720..3927993, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene Beta,beta-carotene 9',10'-oxygenase Neighboring gene Protein kinase domain-containing protein Neighboring gene SPK domain-containing protein Neighboring gene C2H2-type domain-containing protein;DUF659 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
    2. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
    NP_001342020.1
    • Confirmed by transcript evidence
    NP_001342021.1
    • Confirmed by transcript evidence
    NP_001380219.1
    • Confirmed by transcript evidence
    NP_494696.1
    • Confirmed by transcript evidence
    NP_872025.1
    • Confirmed by transcript evidence
    NP_872026.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3919720..3927993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355092.3 → NP_001342020.1  Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A238ULT2
      Conserved Domains (1) summary
      cd03384
      Location:108 → 258
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_001355093.3 → NP_001342021.1  Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A238UKK1
      Conserved Domains (1) summary
      cd03384
      Location:110 → 260
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    3. NM_182225.6 → NP_872025.1  Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872025.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZD1
      Conserved Domains (1) summary
      cd03384
      Location:108 → 258
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    4. NM_182226.5 → NP_872026.1  Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZD2
      Conserved Domains (1) summary
      cd03384
      Location:108 → 258
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    5. NM_062295.6 → NP_494696.1  Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXU1
      Conserved Domains (1) summary
      cd03384
      Location:108 → 258
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    6. NM_001393048.1 → NP_001380219.1  Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A238UKJ7
      Conserved Domains (1) summary
      cd03384
      Location:108 → 258
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein
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