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    polq-1 DNA polymerase theta [ Caenorhabditis elegans ]

    Gene ID: 175810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    polq-1
    Official Full Name
    DNA polymerase theta
    Primary source
    WormBase:WBGene00020964
    Locus tag
    CELE_W03A3.2
    See related
    AllianceGenome:WB:WBGene00020964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Involved in base-excision repair, gap-filling and cellular response to ionizing radiation. Predicted to be located in nucleus. Orthologous to human POLQ (DNA polymerase theta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See polq-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    19
    Sequence:
    Chromosome: III; NC_003281.10 (5791119..5803160, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DNA polymerase Neighboring gene Citrate transport protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-10 Neighboring gene Kinetochore protein Nuf2 homolog Neighboring gene Ras-associating domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Asagoshi K, et al. Nucleic Acids Res, 2012 Jan. PMID 21917855, Free PMC Article
    2. Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis. van Schendel R, et al. Nat Commun, 2015 Jun 16. PMID 26077599, Free PMC Article
    3. Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining. van Schendel R, et al. PLoS Genet, 2016 Oct. PMID 27755535, Free PMC Article
    4. Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes. Harris PV, et al. Mol Cell Biol, 1996 Oct. PMID 8816490, Free PMC Article
    5. BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining. Kamp JA, et al. Nat Commun, 2020 Jul 17. PMID 32680986, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.
      Title: Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.
    2. BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
      Title: BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
    3. Our study provides a step-wise and versatile model for the in vivo mechanism of POLQ action, which explains the molecular nature of mutagen-induced deletion alleles
      Title: Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining.
    4. POLQ is a major driver of inheritable genomic alterations in Caenorhabditis elegans.
      Title: Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis.
    5. non-canonical DNA break repair mechanism generates deletions characterized by an extremely narrow size distribution
      Title: A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, gap-filling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ionizing radiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair via alternative nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase theta
    NP_001367994.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5791119..5803160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379729.2 → NP_001367994.1  DNA polymerase theta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0FLQ6, G4SPM6
      Conserved Domains (2) summary
      cd08638
      Location:1230 → 1602
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      COG1204
      Location:12 → 696
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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