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    rgl-1 Ral guanine nucleotide dissociation stimulator-like 1 [ Caenorhabditis elegans ]

    Gene ID: 180611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgl-1
    Official Full Name
    Ral guanine nucleotide dissociation stimulator-like 1
    Primary source
    WormBase:WBGene00017891
    Locus tag
    CELE_F28B4.2
    See related
    AllianceGenome:WB:WBGene00017891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in epidermal growth factor receptor signaling pathway and positive regulation of vulval development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including coelomocyte; excretory cell; hypodermis; reproductive system; and somatic cell. Orthologous to several human genes including RGL1 (ral guanine nucleotide dissociation stimulator like 1) and RGL3 (ral guanine nucleotide dissociation stimulator like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rgl-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (3210470..3220367, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals. Shin H, et al. PLoS Genet, 2019 May. PMID 31086367, Free PMC Article
    2. Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system. Mardick JI, et al. Dev Biol, 2021 Sep. PMID 33991533, Free PMC Article
    3. Ras effector switching promotes divergent cell fates in C. elegans vulval patterning. Zand TP, et al. Dev Cell, 2011 Jan 18. PMID 21238927, Free PMC Article
    4. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. Frische EW, et al. EMBO J, 2007 Dec 12. PMID 17989692, Free PMC Article
    5. Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Cuppen E, et al. Genome Res, 2007 May. PMID 17416746, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system.
      Title: Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ral guanine nucleotide dissociation stimulator-like 1
    NP_001123140.1
    • Partially confirmed by transcript evidence
    NP_508550.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3210470..3220367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076149.8 → NP_508550.1  Ral guanine nucleotide dissociation stimulator-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SFM6
      Conserved Domains (3) summary
      smart00229
      Location:64 → 191
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:234 → 495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cl00155
      Location:732 → 823
      UBQ; Ubiquitin-like proteins

    2. NM_001129668.5 → NP_001123140.1  Ral guanine nucleotide dissociation stimulator-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123140.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19852
      Conserved Domains (3) summary
      smart00229
      Location:84 → 211
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:254 → 515
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cl00155
      Location:752 → 843
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version

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