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    mlc-1 Myosin regulatory light chain 1 [ Caenorhabditis elegans ]

    Gene ID: 181776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlc-1
    Official Full Name
    Myosin regulatory light chain 1
    Primary source
    WormBase:WBGene00003369
    Locus tag
    CELE_C36E6.3
    See related
    AllianceGenome:WB:WBGene00003369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable myosin heavy chain binding activity. Involved in several processes, including muscle organ development; nematode larval development; and regulation of muscle contraction. Part of muscle myosin complex. Is expressed in anal depressor muscle; body wall musculature; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 10. Orthologous to several human genes including MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (17459210..17460778)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene MFS transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterizing a strong pan-muscular promoter (Pmlc-1) as a fluorescent co-injection marker to select for single-copy insertions. El Mouridi S, et al. MicroPubl Biol, 2020 Sep 3. PMID 32908967, Free PMC Article
    2. Regulatory myosin light-chain genes of Caenorhabditis elegans. Cummins C, et al. Mol Cell Biol, 1988 Dec. PMID 3244358, Free PMC Article
    3. Segregation of holocentric chromosomes at meiosis in the nematode, Caenorhabditis elegans. Albertson DG, et al. Chromosome Res, 1993 May. PMID 8143084
    4. Functions of the Caenorhabditis elegans regulatory myosin light chain genes mlc-1 and mlc-2. Rushforth AM, et al. Genetics, 1998 Nov. PMID 9799259, Free PMC Article
    5. Microinjected DNA from the X chromosome affects sex determination in Caenorhabditis elegans. McCoubrey WK, et al. Science, 1988 Nov 25. PMID 2973125

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle organ development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of muscle myosin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of muscle myosin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Myosin regulatory light chain 1
    NP_510829.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      17459210..17460778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078428.8 → NP_510829.2  Myosin regulatory light chain 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510829.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19625, Q9BL98
      Conserved Domains (1) summary
      COG5126
      Location:13 → 159
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19625.1

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