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    meg-1 Protein meg-1 [ Caenorhabditis elegans ]

    Gene ID: 181502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    meg-1
    Official Full Name
    Protein meg-1
    Primary source
    WormBase:WBGene00010492
    Locus tag
    CELE_K02B9.1
    See related
    AllianceGenome:WB:WBGene00010492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in P granule disassembly and germ cell proliferation. Located in P granule. Is expressed in germ line; germline blastomere; and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See meg-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (13927036..13929634, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein meg-2 Neighboring gene pseudo Neighboring gene Transcription factor elt-3 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos. Cassani M, et al. Development, 2022 Nov 1. PMID 36196602, Free PMC Article
    2. Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation. Day NJ, et al. FEBS Lett, 2018 Nov. PMID 30264890, Free PMC Article
    3. C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Kapelle WS, et al. Genesis, 2011 May. PMID 21305687
    4. MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegans. Leacock SW, et al. Genetics, 2008 Jan. PMID 18202375, Free PMC Article
    5. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Wang JT, et al. Elife, 2014 Dec 23. PMID 25535836, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that meg-1 and meg-2 differentially interact with the nanos family nos-1, nos-2 and nos-3 for germ cell proliferaiton.
      Title: C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule disassembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in multicellular organismal reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein meg-1
    NP_510319.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13927036..13929634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077918.8 → NP_510319.1  Protein meg-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21126
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21126.2

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