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    flcn-1 Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flcn-1
    Official Full Name
    Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein
    Primary source
    WormBase:WBGene00017699
    Locus tag
    CELE_F22D3.2
    See related
    AllianceGenome:WB:WBGene00017699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Is expressed in several structures, including body wall musculature; excretory cell; intestine; spermatheca; and vulva. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flcn-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    19
    Sequence:
    Chromosome: II; NC_003280.10 (6928763..6947900)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Neighboring gene Homeobox protein ceh-38;One cut domain family member Neighboring gene Sex-determining transformer protein 2 Neighboring gene Translation initiation factor eIF2B subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycogen: A must have storage to survive stressful emergencies. Possik E, et al. Worm, 2016 Apr-Jun. PMID 27383221, Free PMC Article
    2. Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner. Gharbi H, et al. Aging Cell, 2013 Aug. PMID 23566034
    3. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells. Haley R, et al. PLoS Genet, 2018 Aug. PMID 30138370, Free PMC Article
    4. FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. Possik E, et al. PLoS Genet, 2015 Oct. PMID 26439621, Free PMC Article
    5. The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing. Zhang Y, et al. Nat Commun, 2021 Mar 19. PMID 33741976, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. F22D3.2 acts as a novel modulator of C. elegans lifespan.
      Title: Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    prim_transcript

    • Loc: 6943885-6944021 standard_name = F22D3.9.1

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein
    NP_001022108.1
    • Partially confirmed by transcript evidence
    NP_001263661.1
    • Confirmed by transcript evidence
    NP_001293478.1
    • Confirmed by transcript evidence
    NP_001293480.1
    • Confirmed by transcript evidence
    NP_001317868.1
    • Confirmed by transcript evidence
    NP_001368184.1
    • Confirmed by transcript evidence
    NP_001368185.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6928763..6947900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330952.3 → NP_001317868.1  Folliculin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      K0M7B5
      Conserved Domains (2) summary
      pfam11704
      Location:116 → 345
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
      pfam16692
      Location:405 → 611
      Folliculin_C; Folliculin C-terminal domain

    2. NM_001276732.2 → NP_001263661.1  Folliculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      J7S130
      Conserved Domains (2) summary
      pfam11704
      Location:117 → 348
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
      pfam16692
      Location:416 → 610
      Folliculin_C; Folliculin C-terminal domain

    3. NM_001306549.4 → NP_001293478.1  Folliculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FCY3
      Conserved Domains (2) summary
      pfam11704
      Location:116 → 345
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
      pfam16692
      Location:401 → 607
      Folliculin_C; Folliculin C-terminal domain

    4. NM_001306551.3 → NP_001293480.1  Folliculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293480.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FMZ4
      Conserved Domains (2) summary
      pfam11704
      Location:116 → 348
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
      pfam16692
      Location:408 → 614
      Folliculin_C; Folliculin C-terminal domain

    5. NM_001381469.1 → NP_001368184.1  UDENN FLCN/SMCR8-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZM3
      Conserved Domains (1) summary
      pfam11704
      Location:117 → 340
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport

    6. NM_001026937.5 → NP_001022108.1  Folliculin DENN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5DX40
      Conserved Domains (1) summary
      pfam16692
      Location:80 → 286
      Folliculin_C; Folliculin C-terminal domain

    7. NM_001381470.1 → NP_001368185.1  Folliculin DENN domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F533
      Conserved Domains (1) summary
      pfam16692
      Location:57 → 251
      Folliculin_C; Folliculin C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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