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    sek-3 mitogen-activated protein kinase kinase [ Caenorhabditis elegans ]

    Gene ID: 180773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sek-3
    Official Full Name
    mitogen-activated protein kinase kinase
    Primary source
    WormBase:WBGene00022613
    Locus tag
    CELE_ZC449.3
    See related
    AllianceGenome:WB:WBGene00022613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable MAP kinase kinase activity. Predicted to be involved in stress-activated MAPK cascade. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sek-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (5018018..5020944)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SCP domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Apple domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-His Neighboring gene Apple domain-containing protein Neighboring gene Ac108

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. Munkácsy E, et al. PLoS Genet, 2016 Jul. PMID 27420916, Free PMC Article
    2. Conserved statin-mediated activation of the p38-MAPK pathway protects Caenorhabditis elegans from the cholesterol-independent effects of statins. Goncalves IL, et al. Mol Metab, 2020 Sep. PMID 32339771, Free PMC Article
    3. The evolutionarily conserved ESRE stress response network is activated by ROS and mitochondrial damage. Tjahjono E, et al. BMC Biol, 2020 Jun 29. PMID 32600387, Free PMC Article
    4. Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity. Tjahjono E, et al. PLoS Genet, 2022 Mar. PMID 35275914, Free PMC Article
    5. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. Gaeta AL, et al. PLoS Genet, 2022 Aug. PMID 35984862, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DLK-1, SEK-3 and PMK-3 have roles in C. elegans adaptation to disruption of the mitochondrial electron transport chain, and in extended lifespan
      Title: DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase
    NP_001380000.1
    • Confirmed by transcript evidence
    NP_741776.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5018018..5020944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171675.7 → NP_741776.1  mitogen-activated protein kinase kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPS3
      Conserved Domains (1) summary
      cl21453
      Location:104 → 393
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001392771.1 → NP_001380000.1  mitogen-activated protein kinase kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23326
      Conserved Domains (1) summary
      cl21453
      Location:64 → 353
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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