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    pif-1 ATP-dependent DNA helicase;ATP-dependent DNA helicase PIF1 [ Caenorhabditis elegans ]

    Gene ID: 171665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pif-1
    Official Full Name
    ATP-dependent DNA helicase;ATP-dependent DNA helicase PIF1
    Primary source
    WormBase:WBGene00004028
    Locus tag
    CELE_Y18H1A.6
    See related
    AllianceGenome:WB:WBGene00004028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-3' DNA helicase activity. Predicted to be involved in DNA duplex unwinding and DNA replication. Predicted to be located in mitochondrion and nucleus. Predicted to be active in replication fork. Is expressed in intestine. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pif-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (719929..731078)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CBF1-interacting co-repressor CIR N-terminal domain-containing protein;Cir_N domain-containing protein Neighboring gene Rap-GAP domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene RGS domain-containing protein Neighboring gene Ovule protein Neighboring gene ncRNA Neighboring gene COLlagen

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Yoneda T, et al. J Cell Sci, 2004 Aug 15. PMID 15280428
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase;ATP-dependent DNA helicase PIF1
    NP_001293173.1
    • Confirmed by transcript evidence
    NP_001293174.1
    • Confirmed by transcript evidence
    NP_001293175.1
    • Confirmed by transcript evidence
    NP_490774.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      719929..731078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058373.6 → NP_490774.2  ATP-dependent DNA helicase PIF1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490774.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFV7
      Conserved Domains (1) summary
      cl21455
      Location:245 → 541
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001306245.3 → NP_001293174.1  ATP-dependent DNA helicase PIF1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIU3
      Conserved Domains (2) summary
      COG0507
      Location:97 → 521
      RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
      cd18037
      Location:143 → 314
      DEXSc_Pif1_like; DEAD-box helicase domain of Pif1

    3. NM_001306244.3 → NP_001293173.1  ATP-dependent DNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CL86
      Conserved Domains (2) summary
      COG0507
      Location:5 → 344
      RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
      cl28899
      Location:6 → 137
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    4. NM_001306246.3 → NP_001293175.1  ATP-dependent DNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293175.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJZ4
    Nucleotide Protein
    Heading Accession and Version

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