mom-1 Protein-serine O-palmitoleoyltransferase porcupine [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mom-1
Official Full Name: Protein-serine O-palmitoleoyltransferase porcupine
Primary source: WormBase:WBGene00003394
Locus tag: CELE_T07H6.2
See related: AllianceGenome:WB:WBGene00003394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; asymmetric protein localization involved in cell fate determination; and embryonic morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mom-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (6293112..6298305)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T07H6.2 (e-PCR)
- UniSTS:314931

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoleoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoleoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of Wnt protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway, regulating spindle positioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein lipidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein palmitoleylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein-serine O-palmitoleoyltransferase porcupine

NP_509054.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6293112..6298305

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076653.6 → NP_509054.1 Protein-serine O-palmitoleoyltransferase porcupine [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509054.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16142, Q22329

Conserved Domains (1) summary

cl00738
Location:158 → 325

MBOAT; MBOAT, membrane-bound O-acyltransferase family