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    ufm-1 Ubiquitin-fold modifier 1 [ Caenorhabditis elegans ]

    Gene ID: 176100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ufm-1
    Official Full Name
    Ubiquitin-fold modifier 1
    Primary source
    WormBase:WBGene00044324
    Locus tag
    CELE_ZK652.3
    See related
    AllianceGenome:WB:WBGene00044324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in response to endoplasmic reticulum stress and reticulophagy. Predicted to be active in cytoplasm and nucleus. Is expressed in egg-laying apparatus; hermaphrodite gonad; intestine; neurons; and seam cell. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 14. Orthologous to human UFM1 (ubiquitin fold modifier 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ufm-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003281.10 (7858979..7859512)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ApaG domain-containing protein Neighboring gene 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Neighboring gene ncRNA Neighboring gene Mitochondrial import receptor subunit TOM7 homolog Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR structure of conserved eukaryotic protein ZK652.3 from C. elegans: a ubiquitin-like fold. Cort JR, et al. Proteins, 2002 Sep 1. PMID 12211038
    2. Structural basis for Ufm1 recognition by UfSP. Kim KH, et al. FEBS Lett, 2018 Jan. PMID 29251776
    3. The MPN domain of Caenorhabditis elegans UfSP modulates both substrate recognition and deufmylation activity. Ha BH, et al. Biochem Biophys Res Commun, 2016 Aug 5. PMID 27240952
    4. The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans. Hertel P, et al. J Biol Chem, 2013 Apr 12. PMID 23449979, Free PMC Article
    5. Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy. Colin E, et al. Am J Hum Genet, 2016 Sep 1. PMID 27545681, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein ufmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-fold modifier 1
    NP_498705.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7858979..7859512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066304.8 → NP_498705.1  Ubiquitin-fold modifier 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34661
      Conserved Domains (1) summary
      cd01766
      Location:14 → 88
      Ubl_UFM1; ubiquitin-like (Ubl) domain found in ubiquitin fold modifier 1 (UFM1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34661.1

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