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    rpi-2 Protein XRP2 [ Caenorhabditis elegans ]

    Gene ID: 187156, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpi-2
    Official Full Name
    Protein XRP2
    Primary source
    WormBase:WBGene00019536
    Locus tag
    CELE_K08D12.2
    See related
    AllianceGenome:WB:WBGene00019536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in protein localization to non-motile cilium. Located in cilium and periciliary membrane compartment. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpi-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (1711262..1714897)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Proteasome subunit beta Neighboring gene CCHC-type domain-containing protein;CCHC-type zinc finger nucleic acid binding protein Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene Ascaris suum EPICuticlin protein related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mistrafficking of prenylated proteins causes retinitis pigmentosa 2. Zhang H, et al. FASEB J, 2015 Mar. PMID 25422369, Free PMC Article
    2. WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium. Cevik S, et al. Life Sci Alliance, 2023 Aug. PMID 37208194, Free PMC Article
    3. Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment. Kotsis F, et al. Biochem Biophys Res Commun, 2021 Dec 20. PMID 34753064
    4. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Canning P, et al. Cell Rep, 2018 Jan 23. PMID 29420175, Free PMC Article
    5. A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, et al. Mol Syst Biol, 2016 Oct 24. PMID 27777270, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in periciliary membrane compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periciliary membrane compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein XRP2
    NP_500127.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1711262..1714897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067726.3 → NP_500127.2  Protein XRP2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500127.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q966I6
      Conserved Domains (1) summary
      pfam07986
      Location:69 → 187
      TBCC; Tubulin binding cofactor C
    Nucleotide Protein
    Heading Accession and Version

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