K12C11.1 Peptidase M24 domain-containing protein;Xaa-Pro dipeptidase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K12C11.1
Official Full Name: Peptidase M24 domain-containing protein;Xaa-Pro dipeptidase
Primary source: WormBase:WBGene00019673
Locus tag: CELE_K12C11.1
See related: AllianceGenome:WB:WBGene00019673
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See K12C11.1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (1341272..1344692, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K12C11.1 (e-PCR)
- UniSTS:316068

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peptidase M24 domain-containing protein;Xaa-Pro dipeptidase

NP_001293413.1

Confirmed by transcript evidence

NP_490843.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1341272..1344692 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058442.6 → NP_490843.1 Xaa-Pro dipeptidase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490843.1

Status: REVIEWED

UniProtKB/TrEMBL

O44995

Conserved Domains (2) summary

smart01011
Location:12 → 152

AMP_N; Aminopeptidase P, N-terminal domain

cd01087
Location:189 → 465

Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
NM_001306484.3 → NP_001293413.1 Peptidase M24 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293413.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RXW2

Conserved Domains (1) summary

cl00279
Location:1 → 197

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...