U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    plst-1 Calponin-homology (CH) domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3564941, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    plst-1
    Official Full Name
    Calponin-homology (CH) domain-containing protein
    Primary source
    WormBase:WBGene00022425
    Locus tag
    CELE_Y104H12BR.1
    See related
    AllianceGenome:WB:WBGene00022425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76; congenital diaphragmatic hernia; and nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1); PLS1 (plastin 1); and PLS3 (plastin 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See plst-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (1289627..1296897)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene 30S ribosomal protein S15;DNA_pol_B_exo1 domain-containing protein;Transposase;Uncharacterized protein Neighboring gene ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase Neighboring gene PHD-type domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis. Silva AM, et al. J Cell Biol, 2023 Jan 2. PMID 36219157, Free PMC Article
    2. Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset. Priti A, et al. Nat Commun, 2018 Nov 8. PMID 30410005, Free PMC Article
    3. Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. Ding WY, et al. J Cell Biol, 2017 May 1. PMID 28400443, Free PMC Article
    4. Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism. Gallotta I, et al. Hum Mol Genet, 2016 Jun 15. PMID 27260405, Free PMC Article
    5. Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy. Walsh MB, et al. BMC Biol, 2020 Sep 16. PMID 32938453, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the evolutionarily conserved actin bundling/cross-linking protein plastin is instrumental for the generation of potent cortical actomyosin contractility in the Caenorhabditis elegans zygote
      Title: Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis.
    2. We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype
      Title: Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Calponin-homology (CH) domain-containing protein
    NP_001294438.1
    • Confirmed by transcript evidence
    NP_001294439.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1289627..1296897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307510.2 → NP_001294439.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMA7
      Conserved Domains (2) summary
      smart00033
      Location:246 → 348
      CH; Calponin homology domain
      pfam00307
      Location:1 → 94
      CH; Calponin homology (CH) domain

    2. NM_001307509.2 → NP_001294438.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBU8
      Conserved Domains (2) summary
      smart00033
      Location:243 → 345
      CH; Calponin homology domain
      pfam00307
      Location:1 → 94
      CH; Calponin homology (CH) domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools