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    mdt-18 Mediator of RNA polymerase II transcription subunit 18 [ Caenorhabditis elegans ]

    Gene ID: 183844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdt-18
    Official Full Name
    Mediator of RNA polymerase II transcription subunit 18
    Primary source
    WormBase:WBGene00007018
    Locus tag
    CELE_C55B7.9
    See related
    AllianceGenome:WB:WBGene00007018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED18 (mediator complex subunit 18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mdt-18 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (6492720..6495253, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Chromo domain-containing protein Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene ncRNA Neighboring gene Lariat debranching enzyme Neighboring gene Unconventional prefoldin RPB5 interactor Neighboring gene Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene Protein-tyrosine phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
    2. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
    3. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
    4. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
    5. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription initiation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mediator of RNA polymerase II transcription subunit 18
    NP_001380190.1
    • Confirmed by transcript evidence
    NP_491869.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6492720..6495253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392449.1 → NP_001380190.1  Mediator of RNA polymerase II transcription subunit 18 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCJ5
      Conserved Domains (1) summary
      pfam09637
      Location:5 → 157
      Med18; Med18 protein

    2. NM_059468.7 → NP_491869.1  Mediator of RNA polymerase II transcription subunit 18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491869.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q966M5
      Conserved Domains (1) summary
      pfam09637
      Location:26 → 218
      Med18; Med18 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q966M5.1

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