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    rabs-5 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rabs-5
    Official Full Name
    FYVE-type domain-containing protein
    Primary source
    WormBase:WBGene00021538
    Locus tag
    CELE_Y42H9AR.3
    See related
    AllianceGenome:WB:WBGene00021538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in pinocytosis and receptor-mediated endocytosis. Is expressed in PQR; amphid neurons; head; phasmid neurons; and ray neurons. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rabs-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (8104284..8107602, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein lifeguard 2 Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene ELM2 domain-containing protein Neighboring gene PDZ GRASP-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endosome maturation factors Rabenosyn-5/VPS45 and caveolin-1 regulate ciliary membrane and polycystin-2 homeostasis. Scheidel N, et al. EMBO J, 2018 May 2. PMID 29572244, Free PMC Article
    2. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. Gengyo-Ando K, et al. EMBO Rep, 2007 Feb. PMID 17235359, Free PMC Article
    3. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
    4. DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans. van der Vaart A, et al. PLoS Genet, 2015 Dec. PMID 26657059, Free PMC Article
    5. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FYVE-type domain-containing protein
    NP_001294172.1
    • Confirmed by transcript evidence
    NP_501352.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8104284..8107602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068951.4 → NP_501352.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3Y4
      Conserved Domains (3) summary
      cl28890
      Location:173 → 218
      FYVE_like_SF; FYVE domain like superfamily
      pfam05605
      Location:21 → 47
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam11464
      Location:521 → 557
      Rbsn; Rabenosyn Rab binding domain

    2. NM_001307243.3 → NP_001294172.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBE5
      Conserved Domains (3) summary
      cl28890
      Location:173 → 218
      FYVE_like_SF; FYVE domain like superfamily
      pfam05605
      Location:21 → 47
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam11464
      Location:523 → 559
      Rbsn; Rabenosyn Rab binding domain
    Nucleotide Protein
    Heading Accession and Version

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