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    mod-5 Transporter [ Caenorhabditis elegans ]

    Gene ID: 171879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mod-5
    Official Full Name
    Transporter
    Primary source
    WormBase:WBGene00003387
    Locus tag
    CELE_Y54E10BR.7
    See related
    AllianceGenome:WB:WBGene00003387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables serotonin:sodium:chloride symporter activity. Involved in serotonin uptake. Predicted to be located in membrane and presynapse. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in several structures, including nerve ring. Used to study cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anxiety disorder (multiple); depressive disorder (multiple); heart disease (multiple); and substance abuse (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mod-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (3034716..3047794, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene Signal peptidase complex catalytic subunit SEC11 Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene DNA-directed RNA polymerase II subunit RPB7 Neighboring gene C2H2-type domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 1 Neighboring gene Actin-related protein 2/3 complex subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. Ranganathan R, et al. J Neurosci, 2001 Aug 15. PMID 11487610, Free PMC Article
    2. Basal pharyngeal pumping elevated in C. elegans mod-5 mutants. Hiebert T, et al. MicroPubl Biol, 2017 Feb 8. PMID 32550351, Free PMC Article
    3. Precision deletion of the entire coding sequence of the mod-5 locus causes increase in pharyngeal pumping frequency. Brock T, et al. MicroPubl Biol, 2017 Jun 6. PMID 32550363, Free PMC Article
    4. Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off. Mignerot L, et al. Elife, 2024 Apr 2. PMID 38564369, Free PMC Article
    5. The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions in Caenorhabditis elegans. Aprison EZ, et al. Proc Biol Sci, 2022 Nov 30. PMID 36448283, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serotonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin:sodium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serotonin uptake IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serotonin uptake IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Transporter
    NP_491095.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3034716..3047794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058694.4 → NP_491095.3  Transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491095.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q963F3, Q9N3C7
      Conserved Domains (1) summary
      cd11497
      Location:100 → 639
      SLC6sbd_SERT-like; Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version

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