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    sqrd-1 FAD/NAD(P)-binding domain-containing protein;Pyr_redox_2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqrd-1
    Official Full Name
    FAD/NAD(P)-binding domain-containing protein;Pyr_redox_2 domain-containing protein
    Primary source
    WormBase:WBGene00008538
    Locus tag
    CELE_F02H6.5
    See related
    AllianceGenome:WB:WBGene00008538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable FAD binding activity and sulfide:quinone oxidoreductase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Predicted to be active in mitochondrion. Orthologous to human SQOR (sulfide quinone oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqrd-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (14219871..14224440)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans. Mikoláš P, et al. PLoS One, 2013. PMID 23484030, Free PMC Article
    2. Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide. Horsman JW, et al. J Biol Chem, 2016 Mar 4. PMID 26677221, Free PMC Article
    3. Lifespan and healthspan benefits of exogenous H(2)S in C. elegans are independent from effects downstream of eat-2 mutation. Ng LT, et al. NPJ Aging Mech Dis, 2020. PMID 32566245, Free PMC Article
    4. The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide. Budde MW, et al. Genetics, 2011 Oct. PMID 21840852, Free PMC Article
    5. Thiol reductive stress activates the hypoxia response pathway. Ravi, et al. EMBO J, 2023 Nov 15. PMID 37902464, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ER and mitochondrial stress responses are activated in sqrd-1 mutant animals exposed to H2S, but not in wild-type animals.
      Title: Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide.
    2. Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide.
      Title: The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfide:quinone oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfide oxidation, using sulfide:quinone oxidoreductase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FAD/NAD(P)-binding domain-containing protein;Pyr_redox_2 domain-containing protein
    NP_001255798.1
    • Confirmed by transcript evidence
    NP_001255799.1
    • Confirmed by transcript evidence
    NP_001255800.1
    • Confirmed by transcript evidence
    NP_001293941.1
    • Confirmed by transcript evidence
    NP_001294231.1
    • Confirmed by transcript evidence
    NP_001294232.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14219871..14224440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268869.4 → NP_001255798.1  FAD/NAD(P)-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62133
      Conserved Domains (1) summary
      COG0446
      Location:28 → 377
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    2. NM_001268870.4 → NP_001255799.1  FAD/NAD(P)-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRP5
      Conserved Domains (1) summary
      COG0446
      Location:23 → 328
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    3. NM_001307012.3 → NP_001293941.1  Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ADY3
      Conserved Domains (1) summary
      COG0446
      Location:20 → 316
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    4. NM_001268871.3 → NP_001255800.1  FAD/NAD(P)-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRP6
      Conserved Domains (1) summary
      COG0446
      Location:20 → 267
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    5. NM_001307303.3 → NP_001294232.1  Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294232.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M1ZJU1
      Conserved Domains (1) summary
      COG0446
      Location:67 → 183
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    6. NM_001307302.3 → NP_001294231.1  Pyr_redox_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294231.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M1ZJZ0
      Conserved Domains (1) summary
      COG0446
      Location:3 → 134
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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