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    lys-6 LYSozyme [ Caenorhabditis elegans ]

    Gene ID: 178087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lys-6
    Official Full Name
    LYSozyme
    Primary source
    WormBase:WBGene00003095
    Locus tag
    CELE_F58B3.3
    See related
    AllianceGenome:WB:WBGene00003095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in innate immune response and signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lys-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (11626910..11627947, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene LYSozyme Neighboring gene ncRNA Neighboring gene Lysozyme-like protein 5 Neighboring gene NUC153 domain-containing protein Neighboring gene Methionine--tRNA ligase, cytoplasmic;tRNA-binding domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Early-life exposure to mycotoxin zearalenone exacerbates aberrant immune response, oxidative stress, and mortality of Caenorhabditis elegans under pathogen Bacillus thuringiensis infection. How CM, et al. Ecotoxicol Environ Saf, 2024 Mar 1. PMID 38342010
    2. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article
    3. Inducible antibacterial defense system in C. elegans. Mallo GV, et al. Curr Biol, 2002 Jul 23. PMID 12176330
    4. Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response. Mokoena NZ, et al. Med Microbiol Immunol, 2023 Oct. PMID 37672050, Free PMC Article
    5. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas HR, et al. Mol Immunol, 2004 Jul. PMID 15183927

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall macromolecule catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LYSozyme
    NP_502194.1
    • Product from WormBase gene class lys;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11626910..11627947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069793.7 → NP_502194.1  LYSozyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20968
      Conserved Domains (1) summary
      cd06416
      Location:19 → 212
      GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
    Nucleotide Protein
    Heading Accession and Version

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