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    T06D8.9 Store-operated calcium entry-associated regulatory factor [ Caenorhabditis elegans ]

    Gene ID: 174716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T06D8.9
    Official Full Name
    Store-operated calcium entry-associated regulatory factor
    Primary source
    WormBase:WBGene00011529
    Locus tag
    CELE_T06D8.9
    See related
    AllianceGenome:WB:WBGene00011529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T06D8.9 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (11239718..11240986)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FUN14 domain-containing protein fndc-1 Neighboring gene ncRNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 13 Neighboring gene Peroxidase Neighboring gene ncRNA Neighboring gene Apple domain-containing protein Neighboring gene Nuclear receptor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of store-operated calcium entry IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Store-operated calcium entry-associated regulatory factor
    NP_496406.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11239718..11240986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064005.7 → NP_496406.2  Store-operated calcium entry-associated regulatory factor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496406.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22254
      Conserved Domains (1) summary
      pfam06682
      Location:13 → 316
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis
    Nucleotide Protein
    Heading Accession and Version

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