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    T06E6.1 WD repeat-containing protein 74 [ Caenorhabditis elegans ]

    Gene ID: 180039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T06E6.1
    Official Full Name
    WD repeat-containing protein 74
    Primary source
    WormBase:WBGene00011538
    Locus tag
    CELE_T06E6.1
    See related
    AllianceGenome:WB:WBGene00011538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human WDR74 (WD repeat domain 74). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T06E6.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (15393108..15394961, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene Serpentine Receptor, class H Neighboring gene G2/mitotic-specific cyclin-B3 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 74
    NP_506824.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15393108..15394961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074423.5 → NP_506824.1  WD repeat-containing protein 74 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506824.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45757
      Conserved Domains (3) summary
      COG2319
      Location:22 → 286
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:38 → 78
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:27 → 293
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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